KMID : 0605720170230030155
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Journal of the Korean Society of Biological Therapies in Psychiatry 2017 Volume.23 No. 3 p.155 ~ p.163
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Investigation of Clinical Factors Associated with the Prediction of Manic Symptom Improvement in the Hospitalized Manic Subjects with Bipolar Disorder
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Kim Chea-Ri
Park Jin-Wan Pak Doo-Hyun Lee Yeon-Jung Han Sang-Woo Woo Sung-Il Hwang Jae-Uk
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Abstract
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Objectives£ºThis study was aimed to investigate clinical factors associated with the prediction of symptom improvement in hospitalized patients with bipolar disorder, manic episode.
Methods£ºWe performed a retrospective observational study based on the medical records review of 53 bipolar disorder manic patients, who had been hospitalized in the psychiatric ward. During the hospitalization, Young Mania Rating Scales(YMRS) have been measured periodically. Demographic information and clinical characteristics including medications and history of prior hospitalization have been collected in each patient. Linear mixed effect model has been used to assess the effect of clinical factors on the changes of YMRS over time. Selection of clinical factors was conducted using backward elimination with the minimization of Akaike Information Criterion.
Results£ºMean days of hospitalization were 29.74¡¾16.96. Mean YMRS at the admission was 33.64¡¾7.57. Effective factors for the model included YMRS at baseline, combination of mood stabilizer, and the history of prior hospitalization. Predicted YMRS at the discharge was 10.43(95% confidence interval 7.13?13.72).
Conclusion£ºThe current findings suggest the model which may predict the clinical course of the bipolar disorder manic patients. It would be useful to establish the treatment plan for the patients.
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KEYWORD
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Bipolar disorder, Manic, Hospitalization, Clinical course
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